Glaucoma is a still more serious disease of the eye, which I think there is now sufficient evidence to show is sometimes entirely, and very often in considerable part, neuralgic in its origin. Since my attention was directed, some six years ago, to the frequent connection between the so-called rheumatic iritis and neuralgia, I have taken much interest in the subject of acute eye-affections; and the occurrence of one or two cases of glaucoma in personal friends of my own has made this interest even painfully strong. I am necessarily without the means of personally observing glaucoma on the large scale, but I have now seen two cases in which, if I possess any faculty of clinical observation whatever, the whole genesis of the disease was a neuralgic disorder of the trigeminus; and it was to me a melancholy reflection that nothing better than iridectomy in one case, and excision of the eyeball in the other, could be done in the present state of ophthalmic science. There are now a good many recorded instances of neuralgic glaucoma, and Mr. R. Brudenell Carter, of St. George's, and the South London Ophthalmic Hospital, recently assured me that nervous aspect of some form of glaucoma presents itself the strongly to his mind, though he does not commit himself to any theory. Two cases were reported by Mr. Hutchinson, in Ophthalmic Hospital Reports IV. and V.; but the most complete and interesting cases that I have met with are recorded by Dr. Wegner;[15] they are two out of four that occurred within a very short time in the clinic of Prof. Horner at Zurich, and they form the basis of some researches by Wegner into the nature of the influence of the trigeminus upon ocular tension, which will be referred to, along with others, in the chapter on Pathology. The second of these cases is so important that I shall reproduce it in full.