=Scar of penis=; =sclerosis of aortic arch= (Heller’s type?) and slight coronary arteriosclerosis; =calvarium= thin and =dense=; =dura mater thickened= and adherent to calvarium; calcified arachnoidal villi; =chronic= cerebral and cerebellar =leptomeningitis=; =atrophy of frontal lobes=; =granular ependymitis=; =sclerosis of posterior columns= of spinal cord; emaciation; unequal pupils; slight parietal fibrous endocarditis, slight mitral sclerosis; gastro-intestinal atrophy; chronic cystitis; chronic abscess of prostate. The description of the head findings is as follows: Skin exceedingly loose, and the whole skull cap thinned. The diploë are absent. Adhesion with dura easily separated. The dura somewhat thickened, but not distended. Along the longitudinal sinus extensive calcareous granulations adhere to it. The longitudinal sinus does not contain blood, and the inner surface is normal in color. The pia is extensively thickened and opaque and a general subpial exudate exists which is more marked over the vertex where it lifts the pia from the brain surface to the extent of three centimeters in Rolandic, superior frontal, intraparietal, and mesial precentral sulci on each side. The arteries at base are free from atheroma. The temporal lobes are much bound down by adhesions, as is the cerebellum. Post mortem softening is evident. The hemispheres show no asymmetry, but the frontal convolutions are markedly atrophic. The corpus callosum is united to the cortex by old adhesions and has to be dissected away from it. Lateral ventricles contain some slight amount of cloudy fluid, and the pia along the vessels is opaque. Some granulations in ependyma. Brain weight, 1305 grams. Pons and cerebellum, 195 grams. Cord.—Dura much thickened, and the pia corresponds to its appearance in brain with a like exudate. Cross sections of cord show sclerosis of posterior columns. Bacteriologically the _typhoid bacillus_ was cultivated _from the meninges and from the swollen mesenteric lymph nodes_. The blood was negative; the intestines were negative so far as lesions were concerned. The microscopic examination confirmed the clinical diagnosis of GENERAL PARESIS and of TABES, since there was not only an extensive chronic encephalitis, with the usual lymphocytic and plasma cell deposit and irregular gliosis, but also a well marked posterior column sclerosis, not unusual save in its extreme degree. It might be surmised that some difficulty would arise in distinguishing the effects of paretic meningoencephalitis from those of the more recent typhoidal process. The well-known tendency of typhoidal processes to escape polynuclear exudation, at least until frank necrosis has set in, gave rise to the idea that the two mononuclear pictures—that of general paresis and that of typhoidal processes—might be confusing.