The following summary of the pathogenetic effects of _Primula_ were produced from handling and in otherwise coming in contact with the plant, and so far as known the poisonous properties are wholly confined to the leaves. The effects bear a close resemblance to _Anacardium_, _Euphorbium_, _Ranunculus_, _Rhus_, etc. It is evidently deserving of a thorough proving, and it is our intention to attempt one as soon as a reliable preparation can be had. References: (1) _Syme, British Medical Journal_; (2) _London Lancet_; (3) _Homoeopathic World_, March, 1892; (4) _American Homoeopathist_, 1897, p. 429; (5) _New York Medical Journal_, January, 1898, p. 68. (1) 1. Eczema on face. 2. Eczema on face and arms. 3. Moist eczema on face and forearms, papular and excoriated. 4. Severe cracking over joints and fingers as from frost. 5. Great itching of the skin. 6. Eruption appears at night. 7. Eruption and itching worse at night. 8. The itching was intolerable at night. (2) 9. Irritable papular eruption on both hands, followed by desquamation. 10. Papular eruption on chin. 11. Eruption of small papules on a raised base with intolerable itching. (3) 12. Papular eruption (eczematous) on hands, wrists and fingers. 13. Skin red and swollen and itching violently. 14. At night she became feverish, hands and face would burn, then intolerable itching followed by erythema with small papules becoming pustular. 15. Papular eruption itching violently. (4) 16. Confluent blotches on face resembling urticaria. 17. Eruption between fingers which resembles scabies. 18. Desquamation. 19. Purple blotches on dorsal surface of hands. 20. Palmar surface of hands and fingers are stiff and unusable. 21. Deep-seated blisters form on tip of each finger and above and below each phalangeal flexure. 22. Blisters on fingers from which a clear fluid escapes on being pricked. 23. Intense itching and burning accompanies the eruption. (5) 24. Eruption preceded by pricking sensation which gradually changes to a smarting. 25. Skin tumefied and diffuse infiltration with a red serosity, with here and there small fullæ filled with a limpid liquid. 26. Eyelids greatly swollen and covered with large fullæ, eyes half closed. 27. Great tension and redness of skin resembling erysipeias. 28. Desquamation sometimes furfuraceous, sometimes lamellar, involving all of the epidermic layer in such a manner that in some places the papillary layer was exposed. 29. Eyelids stiff and immovable, resembling ptosis. 30. Dryness and heat in palms of hands. 31. Deep infiltration of tissues rendering the parts stiff and immovable. 32. Skin symptoms accompanied by pronounced febrile symptoms.