PREPARATION.--The fresh, ripe berries are macerated in twice their weight of alcohol. (In 1889 Dr. Napier called attention to _Solanum Carolinense_ as a remedy in the treatment of epilepsy, stating that it was used as a domestic remedy in the South for convulsions and "that he had successfully prescribed it in his practice." Dr. Charles S. Potts, of the University of Pennsylvania, contributes a paper _Therap. Gazette_, Dec., 1895, on the remedy, giving some new points, from which the following is condensed:) At the clinic for nervous diseases of the University Hospital, _Solanum Carolinense_ was tried in a series of twenty-five cases, twenty-one of which were idiopathic, three organic, and one probably so. Of these, eight of the idiopathic cases either did not return after the first visit or else were not under observation sufficiently long to offer a fair test. In the remaining seventeen cases the following results were obtained--viz., five, two of them organic, were not improved. In the remaining twelve the results showed more or less benefit from the use of the drug. The five cases in which no improvement was noted were afterwards placed upon other treatment, either antipyrin and bromide of ammonium or the mixed bromides with amelioration of the symptoms in four; in the remaining one no drug seemed to be of service. The dose used at first was 10 drops. This dose was found to be useless, and after the first few cases they varied from 30 drops to teaspoonful three or four times daily. No unpleasant effects were observed, excepting a mild diarrhoea in some cases. This was also noticed by Dr. Herdman. He also noticed that in large doses the temperature was lowered and the pulse slowed. In many epileptics diarrhoea is more of a benefit than otherwise. The conclusions derived from the results obtained in seventeen cases are:-- 1. That the drug has a decided influence for good upon the epileptic paroxysm. 2. That this influence is probably not so great or so sure as that obtained by the use of antipyrin and the bromide salts or even of the mixed bromides. 3. That in those cases in which it is of service it relieves the paroxysms, without causing any other unpleasant symptoms, such as are sometimes caused by the use of large doses of the bromides. 4. That the dose ordinarily recommended is too small, and that as much as a teaspoonful or more four times daily is often needed to secure results. The following are some of the cases in which the remedy seemed to act beneficially: