Another took ten drops, three times a day, for five days, when the quantity of urine and brick dust deposit were so unusual that her interest in scientific investigation suddenly ceased. About a year since, there came for treatment a patient who had suffered long from both disease and treatment of the bladder. _Thlaspi_ 2x and later five drop doses of the tincture expelled great quantities of sand, and was followed by complete relief of the bladder symptoms and the disappearance of rheumatic pains that had been supposed incurable. Another case of similar bladder irritation and marked evidences of gout was promptly relieved. _Thlaspi_ also has a reputation in the cure of urethritis. THYROID. PREPARATION.--The dried thyroid gland of the sheep is triturated in the usual way or an extract may be prepared from the fresh gland. (The following paper on the effects of _Thyroid_ was written by Dr. F. G. OEhme, Roseburg, Oregon:) The _Thyroid_, especially if used continually or in large doses, _causes_ the following _symptoms_: 1. Elevation of the temperature. 2. Increase of the heart's action and of the frequency and volume of the pulse, which, however, is more compressible. Walking, even standing, after taking a dose is apt to cause a feeling of faintness and even complete syncope. The heart may become so weak that it cannot endure any overexertion without danger, even death may result. 3. Shortness of breath. 4. Increase or decrease of appetite, sometimes nausea, less frequently vomiting, still less diarrhoea. 5. Improvement in body nutrition generally, more complete absorption of nitrogenous food. But later on nitrogen is excreted in excess of that taken in the food. 6. Loss of weight. 7. Increase of sexual desire. 8. Menses profuse, prolonged or more frequent, rarely amenorrhoea. 9. Increased activity of the mucous membrane, kidneys and skin, which becomes moist and oily, sometimes exfoliation of the epidermis. 10. Rapid growth of the skeleton in the young with softening and bending of those bones which have to bear weight. 11. A disease closely resembling exophthalmic goitre. A cataleptic improved under large doses of _Thyroid_, but when the dose of 75 grs. a day was reached symptoms like those of exophthalmic goitre developed with a pulse of 160, but no glandular swelling. When the _Thyroid_ was discontinued the catalepsy grew worse, the exophthalmic goitre better; when resumed the catalepsy better, the exophthalmic goitre worse. A patient, while under _Thyroid_ treatment for myxoedema, took, through a misunderstanding, in eleven days nearly 3 ounces of the dessicated _Thyroid_, whereupon tachycardia, pyrexia, insomnia, tremor of the limbs, polyuria, albuminuria, and glucosuria, in short, a disease similar to exophthalmic goitre developed. _Thyroid_ has been _used_ with benefit in the following _diseases_: 1. Arrested development in children, cretinism, idiotism.