2. Myxoedema. [The extirpation of the entire _Thyroid_ produces a disease resembling myxoedema.] 3. Simple goitre. 4. Excessive obesity with tendency to weakness and anæmia. 5. Melancholia functional insanity, where improvement has taken place up to a certain point and then remains so. 6. Defective secretion of milk during lactation when connected with reappearance of menses. _Thyroid_ will suppress the latter and increase and enrich the milk. 7. In fractures of the bones in which consolidation does not promptly occur. 8. Hypertrophy of cicatricial tissue resembling keloid, possibly true keloid. _Doses:_ Either the fresh gland of the sheep prepared like food or the extract, or in the dessicated state, of the latter may be given from 2-3 grs., or more or less, once a day (at night) or oftener. The _Thyroid_ is _contra-indicated_ in tuberculous persons, as they are apt to lose quickly in weight, over two pounds in twenty-four hours. Rheumatic and anæmic symptoms are more frequently aggravated than improved. As the _Thyroid_ is a powerful remedy, the following should be always remembered: There is a decided difference with regard to individual toleration, some are very susceptible. The pulse should be watched regarding frequency and quality. The least effort or exertion will increase it even to 160, hence some cases should be kept in bed or at least very quiet and tranquil even for a time after the remedy has been discontinued. Deaths have taken place after a few days' treatment. If _Thyroid_ is not taken for myxoedema the patient should be weighed at least every two weeks, and if pathogenetic symptoms, called thyroidism, appear the remedy should be discontinued or reduced. If softening of the bones has been caused it may be necessary to restrict the use of the legs or to use splints. _Thyroid_ seems to have a cumulative effect. In many cases a liberal diet should be prescribed to avoid injurious consequences. TRYCHOSANTHES DIOICA. NAT. ORD., Cucurbitaceæ. COMMON NAME, Patal. PREPARATION.--One part of the entire fresh plant is macerated in two parts by weight of alcohol. (In 1893 H. L. Saha, homoeopathic practitioner, Pabna, Bengal, sent the following to _Hom. Recorder_:) _Trychosanthes dioica_ (Bengali name, Patal). It belongs to the order of _Cucurbitaeæ_, is a creeper, flowering in all seasons, but chiefly in spring. It is a native of Bengal. Its fruit is called Patal, and is used by the natives as one of their chief curry. The plant and its root are used by the native physicians in various maladies. Its action is mainly upon the liver and intestines. The decoction of the root is generally used by the mother physicians for removing costiveness, especially where there is a derangement of the functions of the liver.