On the fifteenth of February, 1839, I felt the precursory symptoms of a new attack, which really did break out in all its fury on the 16th, and continued on the 17th and 18th. I now caused 5 grains of my calculi to be triturated in my presence with 95 grains of sugar of milk, according to the fashion of Hahnemann, and took 1/2 grain in the evening of the 17th, another 1/2 grain in the morning of the 18th. On this day I passed very turbid urine with a considerable quantity of gravel; however, in the region where the ureter dips into the bladder, I experienced an uncomfortable sensation, but was well otherwise. On the 19th I was obliged to visit a patient at the distance of two miles; on my journey I felt that the calculus was descending into the bladder; the urine which I emitted shortly afterwards was very turbid and bloody. That same evening, after returning home, I felt the stone in the bulb of the urethra, and on the morning of the 20th it came off during stool, but unfortunately got lost among the excrement. To judge from my feeling it must have been larger than any of the preceding calculi, and also rougher, for its passage through the urethra was very painful and followed by an oozing out of blood. The uncomfortable feeling in the region of the left kidney never disappeared completely; it became especially painful when pressing upon that place, when riding on horseback or in a carriage, when taking exercise or turning the body. It seems to me that the whole pelvis of the kidneys must have been full of gravel and calculi. I now took 1/2 grain at intervals of eight days; the result was that I passed gravel and small calculi at every micturition. On the 30th of November my condition got worse, and I continued to take 1/2 grain of _Calc. ren. præp._, at longer or shorter intervals, until October 18th, 1840. After this period I ceased to pass any gravel, and I felt entirely well. On the 3d of February I passed some more gravel. Another dose of 1/2 grain of _Lapis renalis_; another dose on June 3d. On June 17th precursors of another attack; on the 18th vomiting accompanied by all the frightful circumstances which I have detailed above; the vomiting of mucus, bile, ingesta, continued at short intervals until the 26th; my tongue was coated with yellow mucus, and my appetite had completely disappeared. _Bryon., Nux v._ and _Pulsat._ relieved the gastric symptom; on the 26th, in the afternoon, I passed a calculus of the size of a pea. I now resume the use of _Calc. ren. præp._ in 1/2 grain doses, at irregular intervals. On the 23d of October I passed a calculus of the size of a pea, without vomiting; there were no other precursory symptoms except the uncomfortable feeling in the region of the kidney a few days previous. I have felt well ever since and free from all complaint, although I continue the occasional use of 1/2 a grain of _Calc. ren. præp._, lest I should have a relapse.