"The forty other cases ran courses somewhat similar to the three cited--all having been apparently cured. Yet I am not satisfied beyond a doubt, that any of those patients were completely cured except those whose trouble of the heart were functional, like the second case cited. And it is possible and even probable that in weather of a heavy atmosphere or when it is surcharged with electricity, or if the patient be subjected to great excitement or sudden or violent commotion or exercise he may suffer again therewith. That the medicine has a remarkable influence on the diseased heart must, I think, be admitted. From experiments on dogs and cats made by myself, it appears to influence the vagi and cardio inhibitory centres, and diminishes the pulse rate, increases the intraventricular pressure, and thus filling the heart with blood causes retardation of the beat and an equilibrium between the general blood pressure and force of the beat. Cardiac impulse, after a few days' use of the _Cratægus_, is greatly strengthened and yields that low, soft tone so characteristic of the first sound, as shown by the cardiograph. The entire central nervous system seems to be influenced favorably by its use; the appetite increases and assimilation and nutrition improve, showing an influence over the sympathetic and the solar plexus. Also a sense of quietude and well-being rests on the patient, and he who before its use was cross, melancholic and irritable, after a few days of its use shows marked signs of improvement in his mental state. I doubt if it is indicated in fatty enlargement. The dose which I have found to be the most available is from ten to fifteen drops after meals or food. If taken before food it may, in very susceptible patients, cause nausea. I find also that after its use for a month it may be well to discontinue for a week or two, when it should be renewed for another month or so. Usually three months seem to be the proper time for actual treatment, and after that only at such times as a warning pain of the heart or dyspnoea may point out. (The _Kansas City Medical Journal_, 1898, contained a paper on the remedy, by Dr. Joseph Clements, from which the following pertinent extracts are taken):