In consequence of the premature death of Ponce de Leon, the expedition was given up, and little more was known of these regions until 1538, when Hernandez de Soto, having been made Governor of Cuba, and Adelantado of Florida, undertook, with a company of six hundred men, to explore these his western dominions. He penetrated Florida, Georgia, Tennessee and Kentucky, and struck the Mississippi not far from the place now known as the Chickasaw Bluffs. Thence he passed over to the Red River, and descending that, had nearly reached its mouth, when he was seized with a sudden fever, and died. To prevent his body from falling into the hands of the Indians, it was sunk in the stream at the mouth of Red River, near its junction with "_the father of waters_." The expedition of de Soto consumed four years, during which, his adventures, among the various tribes and nations then teeming in these quiet regions, were diversified and full of the most romantic interest. He was succeeded in 1542 by Lewis de Moscoso, or Mucoso, who, with none of the address or enterprise of de Soto, found himself and his small company, now reduced by disease and constant warfare with the natives, to about three hundred men, encompassed with difficulty, and in danger of being entirely cut off. They built seven brigantines, probably the first specimens of scientific ship building on the Mississippi, and then dropped down the river. Pursued by thousands of exasperated Indians in their canoes, harrassed, wounded, and some of them slain, the miserable remnant at length found their way out of the river, about the middle of July. No sooner had they put to sea, than a violent tempest arose; when another calamity befell them, which will be feelingly understood by many of the navigators of these waters, in our own day. I will give it in the language of the historian, who was one of the party. "While they were in this tempest, in great fear of being cast away, they endured an intolerable torment of an infinite swarm of musketoes, which fell upon them, which, as soon as they had stung the flesh, it so infected it, as though they had been venomous. In the morning, the sea was assuaged, and the wind slacked, but not the musketoes; for the sails, which were white, seemed black with them in the morning. Those which rowed, unless others kept them away, were not able to row. Having passed the fear and danger of the storm, beholding the deformities of their faces, and the blows which they gave themselves to drive them away, one of them laughed at another."