VI. William Lawrence, aged 18 years, unprotected, became sick on Saturday, April 17th. On Sunday taken to the Alms House, and on Wednesday, 21st was transferred to the Hospital. 21st. Eruption fine and papillary on face; red and scarcely raised on arms. None on legs. Has cough since yesterday. Pulse slow and regular. Tongue brown, and incrusted in centre. Moist on sides. 22nd. Eruption confluent and red. Papulo-vesicular on face and arms. Flat, dry, and copious all over the trunk. Scattered and small on legs and feet. Pulse small and regular. Tongue loaded and brown in middle. Eyes sparkling. Is delirious and very restless. 23rd. Eruption very copious all over the body, rising vesicular from red margin. Pulse small and slow. Tongue loaded, furred, and yellow. Head and back easier. Has slept well. Face deeply suffused with red. 24th. Cough. Eruption flat, indented centres, dark in places. It is now coming out on legs. Pulse small and firm. Skin cool. Much uneasiness and hurried breathing. 25th. Dead at seven A. M. This man had been bled twice before his admission, and once again on the 22nd. Cold affusions had been freely used. _Examination_, on the 26th April.--Pericardium sound, but contained much sanguinolent serum. Pleura sound. Lining membrane of pharynx partly destroyed. No ulceration. Tonsils give out pus on pressure. Oesophagus of a dark red, and partly lost its inner membrane. Larynx and trachea injected; but the membrane lining them is entire, without pustules or ulceration. Some frothy effusion in bronchiae. Liver healthy. Spleen large. Omentum sound, and of a natural white colour, traversed by some large veins. Stomach externally of a brown-red colour; and when opened, presents, spread out from the cardiac orifice, dark brown-red streaks; and towards the pyloric orifice and upper side, an extensive surface shaded over with vermillion and darker spots. Near the duodenum, the surface is white. Intestines slightly injected. Bladder dotted all over with bright red spots on its inner surface, which is covered with a fine capillary reticulated structure. VII. An infant, white, unprotected, aged three weeks, child of Clarissa Clarke, who had been inoculated twenty-one years ago. Taken sick on Sunday, 2nd May. Eruption appeared Thursday, 6th. Admitted 9th. 10th. Eruption copious, and in confluent patches, with red bases, and flat vesicular summits. Has also aphthae. 13th. Eruption confluent, in large white patches on face. Throat very sore. 15th. Dead at eight A. M. _Examination._--The stomach of a light colour, perfectly healthy. Folds and plaits of mucous membrane strongly marked. Mucous surface of trachea nearly healthy. VIII. Infant, female, of a woman who died in the Alms House of varioloid disease, shortly after giving birth to this child. It is three weeks old; was admitted Sunday, 25th April, second day of the eruption. Dead on Thursday, 29th. The skin became livid after death..