During the next seven hours, I injected into the bowel ½ oz. of whiskey every half hour. All of it was retained. During this time, the patient occasionally made an unconscious effort to swallow the mucus which accumulated in the fauces, and succeeded so far as to diminish temporarily the rattling and gurgling which now accompanied every respiration. Several times after this effort at swallowing, respiration had to be stimulated by the electrical current. At midnight there was a slight convulsion, after recovery from which the patient again lapsed into the same condition. Gradually there was an increase in the rate both of circulation and respiration, until at 4 A. M., the heart beat 150, and the breathing was 36 per minute. There was no dicrotism, but the heart’s contraction was steadily becoming more feeble and imperfect. The pupils were still widely dilated, the extremities warm, and the temperature 101°. Fifteen minutes later the heart ceased to beat, and death supervened without a struggle. For my own sake, as well as for the good of the profession, I invite the most rigid criticism of the above report. The case in many ways is both interesting and instructive. Was this a case of opium poisoning? The symptoms appear to answer this question in the affirmative. I have so frequently given a similar, and even a larger dose in pressing emergencies, without the least unpleasant effect, that I find it difficult to realize the fact that this patient was fatally poisoned by ½ grain of morphia. Such an unlooked for result has given a terrible shock to my confidence in the safety of large doses of morphia under any circumstances. The heart lesion of it before existed, evidently did not influence the result, as all signs of it were gone when I examined, three hours after the administration of the morphia, and they were not reproduced, even under the stimulation of electricity, atropia and whiskey.