I have had men under my care weighing two hundred and fifty pounds. Upon the occasion of their first visit, having felt their limbs, I have said, "I can diminish your weight by fifty pounds; but these enormous muscles will be increased rather than diminished in size. You must not expect a reduction of more than fifty pounds; but fifty pounds less of fat, distributed among organs overloaded with it, will be highly beneficial to health." Guénaud is far from being thin, but he is strong and muscular, and has the physical and moral energy of a robust young man. His enormous size had rendered him conspicuous in that part of the city where he carried on his business as a baker; but when he had become reduced to the normal size of other men, the change produced considerable sensation, and excited curiosity as to the cause. He has done justice to the treatment which has made him once more a man. I will also do him the justice to say that he has honestly carried out my instructions. A beefsteak or a couple of cutlets, with a very small allowance of vegetables, together with half a cup of coffee, constituted his breakfast. Dinner consisted of meat and a very small quantity of vegetables. From being a great water-drinker, he had come down to an allowance of a bottle or a bottle and a half of liquid in a day. When thirsty he drank but little at a time; and between meals, used to gargle his mouth with fresh cold water. A lady, residing in the town of Montereau, wrote to me in the early part of September, 1849. She was twenty-six years of age, and weighed one hundred and seventy pounds. Her corpulence was increasing to such an extent that she would soon be unable to attend to her household duties. She wished to know if my system of treatment would interfere with her general health, and whether it would prevent her pursuing her usual and indispensable daily avocations. On receiving the necessary explanations, she immediately placed herself under my care, and upon the 23rd of the same month, she informed me that her weight was already considerably less, but that her size remained about the same. A letter of the 12th October following states that she has lost fifteen pounds weight, and that her size is materially diminished. The treatment was continued for some time longer, and never caused the least interference with the discharge of her domestic affairs.