The next step towards procuring a remission is, to open the pores of the skin, which is best done by small doses of James’s powder or emetic tartar, assisted by the common saline draughts, which will be given with most advantage in the act of effervescence, or by _Spiritus Mindereri,_ together with plentiful warm dilution. I once, by way of comparison, tried the two antimonial preparations above mentioned in a number of men ill of this fever, who were sent to the hospital at one time, giving emetic tartar to one half, and James’s powder to the other, and their effects were so similar, that I could perceive no reason for preferring the one to the other. Antimonial medicines seem better adapted to this than any other sort of fever, and may be more freely given in it. These are the most likely means of bringing about a remission; and if this is effected, nothing remains to be done but to throw in as much Peruvian bark as the stomach will bear. But whether from a fresh accumulation of bile, or some other circumstance, it may happen that the fever is kept up; and in this case there is commonly a sense of weight or uneasiness about the _hypochondria_, which seems to indicate that the redundant bile is in the gall bladder or ducts of the liver. In this case a repetition of evacuants is necessary, and calomel will be found to answer remarkably well as a purgative, its stimulus being so extensive as to loosen and bring away bile when the saline purgatives, such as that above mentioned, had failed of having that effect. I have known these to pass through the intestines without relieving the uneasy sensation about the stomach as calomel is found to do; and it will be still more effectual for this purpose, if given alone in a dose, from five to ten grains, and followed some hours afterwards by some other purgative. After this, antimonial medicines are again to be had recourse to; and these, as well as purgative and neutral medicines, are safe and useful in a more advanced stage of this fever than they are in the ship fever; for the strength is not so apt to sink, and the state of the bowels requires them more. Antimonials, however, are to be used sparingly and cautiously as the fever advances; for I have known them, when given only a few days after the first attack, to have the effect, in some constitutions, of making the stomach swell, and of producing a general sense of heat and uneasiness. After the evacuations of the bowels, the anodyne diaphoretic may be very seasonably given in the manner formerly mentioned; for it will not only tend to sooth and procure sleep after the commotion that has been excited, but by its gentle sudorific effect will assist in completing the remission.