The principal point of management in the fevers of this climate is, to throw in the Peruvian bark in proper season. I formerly took occasion to differ from the opinion of those who alledge that little or no discrimination is necessary with regard to the circumstances in which bark is proper in continued fevers. I made fair and unprejudiced trials of this, but always found that some sort of remission, especially towards the beginning of the disease, was necessary, in order to make the use of this medicine safe and proper. The greatest vigilance is indeed required that the administration of it be not omitted when it is at all adviseable, as the course of fevers is very quick and critical in this climate. I have watched many nights with some friends in whose health I was particularly interested, to catch the hour when it might be allowable to give it; and where the propriety of it was somewhat ambiguous, it was usual to qualify it either by conjoining some antimonial or neutral salt with the first doses, or by giving them alternately with it, as has been formerly mentioned. Under the use of these means, the favourable symptoms are, a warm moist skin, a strong steady pulse, with the pulsations under a hundred in a minute, a natural countenance, and being free from delirium. But if the fever should not yield during the first week, but takes an unfavourable turn, the pulse then becomes more small and frequent, there is a general agitation, the tongue is tremulous when put out, there is great thirst and delirium, with a dry and hot skin. In these circumstances, besides the continuation of the antimonials in smaller doses, with the anodyne diaphoretic, and the occasional use of purgatives, blisters now become proper; and we found also camphor combined with nitre an excellent medicine at this period of the disease. Should the patient survive to the end of the second week, the treatment then comes to resemble more and more that of the infectious fever already described. Bark may be given, though there should be no proper remission, and cordials and opiates may be more freely used. Attention to the state of the bowels will still be necessary, since repeated accumulations of bile are apt to occur even in the most advanced stage, and gentle emetics of ipecacuana, as well as laxatives, may be necessary. For the same reason also, greater caution is requisite in the use of pure opiates than in the infectious ship fever before treated of. In order to keep the bowels soluble, it was a very usual practice, and found very useful, to conjoin a few grains of rhubarb with each dose of the bark. 3. Of the YELLOW FEVER.