Amberg: Archives Internationales de Pharmakodynamie et Therapie, 1905. We must especially insist on the fact that high blood-pressure is not a condition essential to arteriosclerosis. It has been shown by Sawada,[201] Groedel,[202] and Ferranini,[203] through measuring the blood-pressure by Riva-Rocci’s instrument, that numerous cases of arteriosclerosis can arise without any increase at all in the blood-pressure. According to Professor Romberg,[204] there is only high blood-pressure in such cases of arteriosclerosis where there is a diseased condition of the kidneys. According to this leading authority on heart diseases, high blood-pressure is one of the earliest symptoms of kidney complication in arteriosclerotic persons. We believe that the high blood-pressure found in kidney diseases may be brought into correlation with the previous statement, by the fact that in such conditions, and especially in sclerosis of the kidneys, the adrenals, if examined, are frequently found to be hypertrophied, as was noted by Parkes Weber,[205] Lemaire, and in four cases of Troin and Rivet.[206] At the last Congress of German Physicians and Naturalists in Dresden, 1907, it was proved by Schur and Wiesel, as also in their previous communications, that the blood of patients affected with kidney diseases contained the characteristic substance that gives the adrenalin reaction with perchloride of iron, and produced mydriasis if dropped into a frog’s eyes. Footnote 201: Deutsche Med. Wochenschrift, No. 12, 1907. Footnote 202: Congress für Innere Medicin, 1907. Footnote 203: Grom. Int. della Soc. Med., xxvi. Footnote 204: Lehrbuch der Krankheiten destergens und der oxlutgefüre. Stuttgart, 1906. Footnote 205: Parkes Weber: Transact. Path. Society, London, lviii, 3. Footnote 206: Gazette des hôpitaux, Juin 14, 1906.