The Elixir Salutis proved immensely popular. It was too much to expect that Anthony should hold the field uncontested; in the 1673 pamphlet one false fabricator was called by name, and in 1680 Anthony advertised to warn against "diverse Persons" who were not only counterfeiting the medicine but spreading the malicious rumor that Anthony was dead. Early in the new century, Catherine, the daughter of the original Rev. Daffy, insisted that she as well as her cousin Anthony had received the valuable formula. But it was Anthony's line that was to prove the more persistent. In 1743, one Susannah Daffy advertised the "Original and Famous Elixir," asserting that she had a brother Anthony who also knew the secret.[19] This Anthony died in 1750 and willed the formula to his niece. But there were others outside the family who long had been making and selling the medicine. For example, the Bow Churchyard Warehouse advertised Daffy's Elixir in the _London Mercury_ during 1721. Without hiding the fact that others were also compounding this "safe and pleasant Cordial ... well-known throughout England, where it has been in great Use these 50 Years," the advertisement concluded: "Those who make tryalof That sold at this [Bow Churchyard] Warehouse will never buy anywhere else."[20] [19] _Ibid._, September 7, 1743. [20] _London Mercury_, London, August 19-26, 1721. Although once lauded by a physician to King Charles II, Daffy's Elixir was never patented. The Elixir invented by Richard Stoughton was, in 1712, the second compound medicine to be granted a patent in England.[21] Stoughton was an apothecary who had a shop at the Sign of the Unicorn in Southwark, Surrey. It was evidently competition, the constant bane of the medicine proprietor's life, that drove him to seek governmental protection. In his specifications he asserted that he had been making his medical mixture for over twenty years. Stoughton was less precise about his formula; indeed, he gave none, but was generous in indicating the remedy's name: "Stoughton's Elixir Magnum Stomachii, or the Great Cordial Elixir, otherwise called the Stomatick Tincture or Bitter Drops." In a handbill, the apothecary did tip his hand to the extent of asserting that his Elixir contained 22 ingredients, but added that nobody but himself knew what they were. The dosage was generous, 50 to 60 drops "in a glass of Spring water, Beer, Ale, Mum, Canary, White wine, with or without sugar, and a dram of brandy as often as you please." This, it was said, would cure any stomach ailment whatever.[22] [21] Richard Stoughton, "Restorative cordial and medicine," British patent 390, 1712. [22] From a broadside, _ca._ 1750, advertising "Dr. Stoughton's Elixir Magnum Stomachum," preserved in the American Antiquarian Society, Worcester, Mass.