[25] George L. Kittredge, "Letters to Samuel Lee and Samuel Sewall relating to New England and the Indians," _Colonial Society of Massachusetts, Transactions_, 1913, vol. 14, pp. 142-186. [26] Bartholomew Brown, Apothecary day book, Salem [1698]; manuscript original preserved in the Library of the Essex Institute, Salem, Massachusetts. [Illustration: Figure 4.--PATRICK ANDERSON, M.D., from a box of Anderson's Scots Pills. From Wootton's _Chronicles of pharmacy_, London, 1910. (_Smithsonian photo 44286-C._)] In the _Boston News-Letter_ for October 4, 1708, Nicholas Boone, at the Sign of the Bible, near the corner, of School-House-Lane, advertised for sale: "DAFFY'S Elixir Salutis, very good, at four shillings and sixpence _per_ half pint Bottle." This may well be the first printed reference in America to an English patent medicine, and it certainly is the first newspaper advertisement for a nostrum. Preceding the _News-Letter_ in colonial America, there had been only one paper, the _Publick Occurrences Both Foreign and Domestic_.[27] This journal had lasted but a single issue. Then its printer had returned to England, where he took up the career of a patent medicine promoter, vending "the only Angelical Pills against all Vapours, Hysterick Fits." The _News-Letter_ had begun with the issue of April 27, 1704, about 4 years before Boone's advertisement for Daffy's remedy made its appearance, but during that time, only one advertisement for anything at all in the medical field had appeared, and that was for a home-remedy book, _The English physician_, by Nicholas Culpeper, Doctor of Physick.[28] This volume was also for sale at Boone's shop. [27] Frank L. Mott, _American journalism_, New York, 1941, pp. 9-10. [28] _Boston News-Letter_, Boston, February 9, 1708.