On adipocire, and its formationWetherill, Charles Mayer
Science
On adipocire, and its formation
Wetherill, Charles Mayer
Adipocere; Fatty acids; Postmortem changes
The adipocire, on February 3d, 1855, until which time it had been kept
in a loosely stoppered bottle, weighed 97 grammes, which is 7·8 per
cent. of the original heart. From 91 grammes the fat was separated
by boiling it with 317 alcohol, filtering hot, pressing powerfully,
and weighing the residue; the latter was bulky, and weighed 40·1,
corresponding to 44 per cent. of the _adipocire_, which contains,
consequently, only 66 per cent. of fat. If the per centage of fat be
calculated from the original weight of the _heart_, it amounts to
only 4·4, which is undoubtedly less than was originally in the heart,
so that, so far from there being a gain of fat in the formation of
the adipocire, there was actually a loss, which accords with the
bottle experiments. The alcoholic solution deposited 16·2 grammes
of a rather dark fat, which was recrystallized from 368 grammes of
alcohol, and yielded 11 grammes of a lighter fat. I was desirous of
retaining a greater portion of this fat for future experiments, and
without proceeding to purify it further, obtained its equivalent. It
melted between 69°-70°, did not crystallize plainly from alcohol, with
which it behaved like stearic acid: a neutral silver salt, deepened
in colour considerably when dried at 100°, and gave only 20·59 and
20·68 per cent. of silver. As decomposition had evidently taken place
in this salt, the baryta compound was prepared by adding acetate of
baryta to the alcoholic solution. The baryta was determined both as
carbonate and by converting into sulphate; there was no difference
in the two results; the baryta of the carbonate was 0·1701, and that
of the sulphate was 0·1700, which corresponds to a per centage of
19·65--stearic acid (Heintz) requires 21·76 per cent., and palmitic
acid 23·62 per cent. of baryta for the neutral salts. I have no doubt
that a further purification will show this to be stearic acid, as might
be expected from the original fat of the heart.
I am not desirous of claiming for these experiments a greater
importance than they deserve, nor any but that the experiments were
carefully performed: they were extended over the greater part of a
year, during which my attention has been particularly directed to
this subject. When the investigation was commenced, I was inclined
to the belief that adipocire was a result of the decomposition
of the blood-forming substances, and this, principally, from the
experiments of Blondeau (see first part of this article) which I have
not seen refuted, and partly from the testimony of those who have had
opportunities of observing the formation of adipocire, and who have
stated that fleshy parts of the body are wholly converted into it.
The formation of the lower terms of the series of fatty acids from
proteine bodies forbids maintaining that this is impossible; but from
what I have seen, and on weighing the evidence of what I have read, my
impression is, that adipocire proceeds from the original fat of the
body.
Public-domain text, read in full here on John Shaqi.
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