Mr. Cock tried to dissuade his patient from having chloroform, severe as the operation would have been without it. In Guy’s Hospital and St. Thomas’s the medical officers had a strong objection to narcotism by inhalation for the first two or three years after the practice was introduced, and chloroform was used much less generally in these institutions than in any other of the hospitals of London; yet it was precisely in these two hospitals that two deaths from chloroform occurred, before any such accident had happened in any other hospital in this metropolis. This circumstance is worthy of the consideration of those who propose to limit the accidents from chloroform by restricting its use to a few great operations. In this case the lungs were reported to be extremely congested. Heart flabby, not particularly distended; about two ounces of fluid blood on the right side; not more than half an ounce on the left. Head.—Much congestion of the dura mater; the grey matter of the brain was dark and congested; fluid was found in the subarachnoid space; and a considerable quantity of it in both ventricles. Kidneys congested.[88] _Case 20_ occurred on September 20th, 1850, at the Cavan Infirmary, Ireland. The case occurred in the practice of Dr. Roe, and I am indebted to Dr. Robert Adams, of Dublin, for a manuscript account of it. The name of the patient was James Jones, and his age twenty-four years. Chloroform was exhibited with the intention of performing amputation below the knee, on account of scrofulous disease of the ankle, with ulceration of the cartilages. The patient was reduced to a state of great debility by the disease, and was suffering from hectic fever, but had no cough. The following is Dr. Roe’s account of the accident:—