“When placed on the operating table the heart’s action was very quick and weak, but he did not appear more faint or pale than usual. I then saw Mr. Nalty, the apothecary, measure one drachm of the chloroform in the small minim glass measure, and pour it upon a little folded lint, which was placed in an oval hollow sponge, held in the hand with a small towel. Recollecting I had used this chloroform in another case, and finding some delay in producing the anæsthetic effects, I directed Mr. Nalty to add thirty drops more to that already put on the lint. I then applied the sponge to the patient’s nose, directing him to keep his mouth shut, and gave the towel into the care of Dr. Halpin, who was on the opposite side of the table, while I went to prepare myself for the operation. Mr. Bird had scarcely screwed up the tourniquette, which had been previously placed on the thigh, while I was examining the state of the circulation in the tibial arteries, and which could not have occupied one minute,—certainly the patient could not have taken fifteen inspirations,—when Dr. Halpin told me the anæsthetic effects were produced. This struck me as being unusually quick and sudden, and on removing the towel from the face, we saw a slight convulsive action of the left eyelid (the eyelids were partially open), and a small quantity of frothy saliva at the mouth. I felt rather uneasy, but not much alarmed, as Dr. Halpin said he had often seen such symptoms from the effects of chloroform, although I had not met with them. On a more minute examination of the heart, the eyes, muscles of the limbs, &c. we found him dead.” Energetic means were used with a view to restore the patient, but without effect. No inspection of the body took place. _Case 21._ The next case of recorded death from chloroform occurred in the Stepney Workhouse. The patient, named John Holden, age not stated, was about to undergo an operation on the penis. It was stated at the inquest that half a drachm of chloroform was administered without effect, and then half a drachm more was applied, when the patient suddenly expired. This death occurred in April 1851.