On Digestive Proteolysis: Being the Cartwright Lectures for 1894Chittenden, R. H. (Russell Henry)
Science
On Digestive Proteolysis: Being the Cartwright Lectures for 1894
Chittenden, R. H. (Russell Henry)
Digestion; Digestive enzymes; Enzymes
formed.
[97] Studien über chemische Processe in der Magenschleimhaut. Pflüger’s
Archiv f. Physiol., Band 50, p. 25. Neue Untersuchungen über das
Lecithalbumin. Liebermann, Ibid., Band 54, p. 573.
There is much that might be said for and against this theory,[98] but
we cannot stop to discuss it here. Like the previous theory, it implies
the production of hydrochloric acid from a chloride or chlorides,
through chemical processes taking place in the stomach-mucosa, and
presumably in the large border-cells of the peptic glands. This
hydrochloric acid, as you know, in the act of secretion, reacts upon
the pepsinogen with which it may come in contact, transforming it into
pepsin. It also has the power of combining with all forms of proteid
matter, not excepting the products of proteolytic action, to form acid
compounds in which the so-combined acid, although equal quantitatively
to the original amount of free acid, is less active in many ways.
Thus, it does not possess in the same degree a destructive action on
the amylolytic ferments;[99] it does not play the same part in aiding
the proteolytic action of pepsin, and its antiseptic power is far from
equal to that of a like amount of free acid.[100]
[98] See discussion by Plósz and Liebermann in Jahresbericht für
Thierchemie, Band 22, p. 260.
[99] Chittenden and H. E. Smith: Studies in Physiol. Chem., Yale
Univer., vol. i., p. 18.
[100] Compare F. O. Cohn: Ueber die Einwirkung des künstlichen
Magensaftes auf Essigsäure-und Milchsäuregährung. Zeitschr. f. physiol.
Chem., Band 14, p. 74.
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