On Digestive Proteolysis: Being the Cartwright Lectures for 1894Chittenden, R. H. (Russell Henry)
Science
On Digestive Proteolysis: Being the Cartwright Lectures for 1894
Chittenden, R. H. (Russell Henry)
Digestion; Digestive enzymes; Enzymes
So separated, the peptone formed in gastric digestion is exceedingly
gummy, but can be transformed into a yellowish powder, very
hygroscopic, of more or less bitter taste, and, when thoroughly dry,
dissolving in water with a hissing sound and with considerable
development of heat, like phosphoric anhydride.[119]
[119] Kühne and Chittenden: Peptones. Studies in Physiol. Chem., Yale
University, vol. 2, p. 14.
I have introduced these dry chemical facts, none of which are
especially new, because I deem them of considerable importance and
because they are not very generally known. In fact, there seems to be
a tendency on the part of some who are more or less familiar with the
advances made in our knowledge of the products of pepsin-proteolysis
to question the existence of these different bodies, or to show at
least a spirit of indifference toward these recent facts which have
been gradually accumulated, and I may say accumulated at the expense
of considerable labor. The time is past for calling the products of
gastric digestion peptones; it is time for a full recognition of the
fact that pepsin-proteolysis is synonymous with the production of a row
of bodies, chemically and physiologically distinct from each other,
each endowed with individuality enough to admit of certain detection,
and all bearing a certain specific and harmonious relationship to their
neighbors, the other members of the series.
Further, it is not enough to admit the formation of a single
intermediate body, midway between syntonin and peptone. The so-called
propeptone of the past is simply a mixture of proteoses, of ever
changing composition, varying with each change in the proportion of the
component proteoses. Each of these proteoses can be detected, under
suitable conditions, in the products of every artificial digestion
as well as in the stomach-contents, and no better measure of the
proteolytic power of the natural stomach-secretion can be devised
than a study of the character of the individual bodies present in the
stomach-contents after a suitable test meal. The proper tests and
separations can be made with a small amount of the filtered fluid, and
much light thrown upon the digestive power of the secretion by even a
rough estimate of the proportion of primary and secondary proteoses
and peptones formed in a given time, after the ingestion of a certain
amount of proteid food.
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