The demand for experiments on animals, in proof of the correctness of his theory, the writer does not feel called upon to satisfy, for, apart from the theory proving itself by explaining all the symptoms the snake-poison produces, it has also stood the test of practical application. It is proven to be correct by the success of the antidote to which it led, and which is the logical outcome of it. After finally attaining a goal one has striven for, it is quite unnecessary to retrace one's steps with a view of ascertaining whether the road that has led up to it is the right and proper one. By a fortuitous concurrence of circumstances, however, even this demand for experiments shall be satisfied in these pages. The writer published his theory of the action of snake-poison in May, 1888, after having practised the strychnine treatment for some years and thoroughly satisfied himself of its efficacy. In the latter part of 1888 accounts of Feoktistow's researches reached this country. His final conclusions to the effect that snake-poison is solely a nerve poison, that it does not destroy protoplasm, and has no effect whatever on the blood to which its destructive potency on animal life can be ascribed, were in complete harmony with the writer's views, in fact, a re-statement of his theory. It was a strange coincidence, or whatever it may be called, that, independent of each other, at almost opposite parts of the globe, and by opposite methods, we had arrived at almost identical conclusions. Those of Feoktistow were drawn from 400 elaborate experiments on animals, both vertebrates and invertebrates, made in the laboratory of Professor Kobert at the University of Dorpat and in that of Professor Owsjannikow at the Imperial Academy of Sciences of St. Petersburg. The writer's conclusions, on the other hand, resulted entirely from a careful and happy analysis of the symptoms observed at the bedside of his patients suffering from snakebite. On one point only, but the most important one, he differs from Feoktistow. The latter shared the fate of all previous experimenters on animals. Though his experiments with snake-poison led him to the correct theory of its action, and even to the correct antidote, his experiments with strychnine and snake-poison were a failure. The animals experimented on died, and, falling into the error of his predecessors, mistaking the functional analogy that exists between the nerve centres of the lower animals and those of man for absolute identity, which does not exist, especially not when they are under the influence of the two poisons, he concluded his researches with the confession that a physiological antidote for snake-poison cannot even be thought of at the present state of science. Although, therefore, Feoktistow's labors would have led to no practical result, they are, nevertheless, a most valuable contribution to science as being the first to demonstrate the action of snake-poison on a strictly