CASE XVII. SPINAL IRRITATION AND LOSS OF USE OF RIGHT LEG—FIVE YEARS’ ILLNESS—OPERATION—CURE. M. B., æt. 30, single; admitted into the London Surgical Home Nov. 15, 1861. _History._—Five years ago first began to suffer pain in the right leg, which was ascribed to sciatica. Fourteen months since this pain became so bad that she could not walk, and she lost all use of her right leg, at the same time felt great weakness and pain in the back, preventing her sitting. For eight months has been confined to a “spinal couch.” Is a spare anæmic woman; dark hair and eyes; dilated pupils; very restless and nervous in her movements, and of a very irritable temper. Has suffered from peripheral irritation since an early age. Nov. 26, 1861. Usual operation performed. Dec. 27. She has gradually improved in health and temper since the operation, and is now quite able to walk about her room without help. She was a long time before her nerve tone was thoroughly restored, but she ultimately got quite strong and continues well. CASE XVIII. HYSTERIA AND SPINAL IRRITATION TWELVE YEARS—FISSURE OF RECTUM, RECENT DURATION—OPERATION—CURE. R. C. R., æt. 35 years, single; admitted into the London Surgical Home April 15, 1861. _History._—Has been suffering for nearly twelve years, at intervals of from six months to six weeks, with pain in the womb and right side, sudden spasms of the limbs, coming on at frequent and irregular intervals. Great pain down the spine and lower part of the back and loins. Has often attacks of severe sickness. Is usually costive. Has lately suffered great pain in defecation. Catamenia regular. Great want of sleep and appetite. Says she is always low-spirited, moping, and listless. Has had much medical treatment. _On examination_ there was found evidence of peripheral excitement of the pudic nerve, and there also existed a fissure of the rectum. April 18. The usual operation performed, and the fissure of the rectum incised. After this time defecation was performed without pain. Sleep, appetite, and cheerful spirits returned. She had no more spasmodic twitchings, but she still complained of intense pain in the back on sitting and walking. She was discharged in June much relieved, but not well. Nov. 9 1861. I received a letter from this lady, stating that she now suffered no pain and was perfectly well. She was stout, and better in every respect than she had been for the last twelve years. CASE XIX. MENORRHAGIA—MENTAL DELUSION—TWO YEARS’ ILLNESS—OPERATION—CURE—SUBSEQUENT MARRIAGE AND PROGENY.