On the mechanism of the physiological action of the cathartics — John Shaqi
On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
The intestines of the rabbit are apparently much more sensitive to the
action of sodium citrate and sulphate than are those of the dog or
cat. Barium chloride, on the contrary, acts with equal strength in all
these animals. In a rabbit, the intestines are always set in active
peristaltic movement by contact with m/8 sodium citrate solution;
and even much more dilute solutions are, as a rule, effective. In a
cat, however, it was found that an m/8 solution of sodium citrate
has practically no effect, while a ⁵⁄₈m solution sets the intestine
in active motion. In a dog also m/8 sodium citrate solution is
usually ineffective. Similarly an m/8 sodium sulphate solution is
inactive in a dog while an m/2 solution of the same salt starts up
distinct peristalsis. In the cat and dog also the peristalsis may be
inhibited by calcium or magnesium chloride, as shown in the following
experiments. The intestines of a cat were exposed in the usual manner,
and an m/8 solution of sodium citrate was applied to the serous surface
of the loops. There was no increased movement. There were then poured
on the loops a few cubic centimetres of a mixture of 5 c.c. ⁵⁄₈m sodium
citrate and 5 c.c. ⁵⁄₈m CaCl_{2}. The loops remained motionless.
After waiting a considerable time (15 minutes), a ⁵⁄₈m solution of
sodium citrate alone was poured on the intestine. Almost immediately
they became very active; and the peristalsis continued until calcium
chloride was again applied. The loops then came to a standstill. The
difference in susceptibility to the action of citrate which exists
between rabbits on the one hand, and dogs and cats on the other, may
be in some way connected with their being herbivorous and carnivorous
animals respectively.
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