As stated above, Bottazzi has found that an extract of the small intestine, which increases the secretion of pancreatic juice, is capable also when injected intravenously of increasing not only the secretory activity of the intestine, but also its peristalsis. As stated in detail in another chapter, the secretion of fluid into the intestine, as well as the peristaltic movements, is inhibited by the administration of calcium or magnesium chloride. This is illustrated by the following experiments:-- 1. Rabbit. Loop 23 cm. long. Loop contained in beginning 0.9 c.c. Fluid secreted during 1st 10 minutes 0.7 c.c. Fluid secreted during 2d 10 minutes 0.6 c.c. 2 c.c. m/8 CaCl_{2} applied locally. Fluid secreted during 1st 10 minutes 0.15 c.c. Fluid secreted during 2d 10 minutes 0.0 c.c. Fluid secreted during 3d 10 minutes 0.0 c.c. 4 c.c. m/8 sodium citrate applied locally. Fluid secreted during 1st 10 minutes 0.4 c.c. Fluid secreted during 2d 10 minutes 0.2 c.c. 2. Rabbit. Loop 25 cm. long. Loop contained in beginning 2.0 c.c. Fluid secreted during 1st 10 minutes 0.8 c.c. Fluid secreted during 2d 10 minutes 0.4 c.c. 2 c.c. m/8 CaCl_{2} applied locally to serous surface. Fluid secreted during 1st 10 minutes following application 0.0 c.c. Fluid secreted during 2d 10 minutes following application 0.0 c.c. 4 c.c. m/8 sodium citrate applied locally. Fluid secreted during 1st 10 minutes 0.6 c.c. 3. Rabbit. Loop 22 cm. long. Loop contained in beginning 2.4 c.c. Fluid secreted during 1st 10 minutes 1.2 c.c. Fluid secreted during 2d 10 minutes 1.15 c.c. 3 c.c. m/8 MgCl_{2} applied locally to serous surface. Fluid secreted during 1st 10 minutes following application 0.0 c.c. Fluid secreted during 2d 10 minutes following application 0.0 c.c. Fluid secreted during 3d 10 minutes following application 0.2 c.c. Although in these experiments the quantity of fluid secreted is small, there is a definite cessation of this excretion following the application of calcium or magnesium chloride. The subsequent administration of sodium citrate in each case causes the secretion to recommence. FOOTNOTES: [34] Recherch. expériment. sur les mouvements des liquides dans les tubes de petits diamètres, Paris, 1828. Comptes rendus t. 19, 1844. Quoted from Hay. [35] Über die Saftbewegung, 1848. [36] L’Union Médicale, 1871, Nos. 50 et 52. Gaz. Méd. de Paris, 1879. [37] Leçons sur les effets des substances toxiques et médicamenteuses, Paris, 1857. [38] Zeitsch. f. Rationelle Medicin, Bd. I, 1851.