On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
Exp. 4. In a second rabbit in which the kidneys were untouched, the
quantity of m/8 NaCl solution introduced was 390 c.c.; about 40 c.c.
of fluid were obtained during three hours from the intestine. This is
10.25% of the amount injected. In the first hour 5 c.c. were secreted
into the loop; in the second hour 7 c.c.; and in the third hour 11.1
c.c. In the rest of the small intestine 17 c.c. were found.
It is clear from these experiments that a considerable proportion of
the fluid injected in this way is eliminated by the intestine. The
quantity is somewhat greater if the kidneys are extirpated. There is,
however, a limit to the amount that can be excreted by the intestine,
and never, as in the case of the kidney, does the amount excreted
approximate the amount injected. The action of such infusions on the
intestine is nevertheless quite similar to that on the kidneys, and
in many other ways the intestine may be regarded as an excretory
organ which can to some extent take on the functions of the kidney.
The intestinal juice contains many substances contained by the urine.
Among the more conspicuous of these is urea, which was shown by Claude
Bernard[66] to be excreted into the intestine as well as the stomach.
He found that it is readily broken up in the intestinal juice, so that
in many cases only salts of ammonia remain.
Pregl[67] demonstrated the presence of urea in the intestinal juice
of the sheep. He found its concentration there to be 0.248%. In the
intestinal juice of rabbits I[68] have found that small quantities of
urea exist both before and after extirpation of the kidneys. It is
present not only in the normal intestinal juice, but also in the fluid
obtained from the intestine after the infusion of large quantities of
m/6 NaCl. Weintrand[69] has demonstrated uric acid in the intestinal
juice.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account