Affections of the spleen, produced by the introduction of foreign matter into the blood, are probably not so readily recognised as similar affections in the lungs and liver. For, although the spleen is often found to be diseased in those who die from infection of the blood, yet it is comparatively seldom that secondary abscesses have been found in it. In the accompanying table, containing twenty-three cases, some morbid appearance, not recognised as peculiarly the result of secondary inflammation, was observed in the spleen in no less than eight instances. So large a proportion of cases renders it probable, that the alterations observed have more than an accidental connexion with the disease of which the patient died, although they presented no characters which could be said to be peculiar to that disease. In well-marked cases of secondary affections of the spleen, one or more well defined, but frequently irregular indurations, of a chocolate colour, may be recognised; such patches are usually seen soon after the commencement of the complaint, and in a very short time become softened or broken down. The rapidity with which they lose their original character, may probably account for their being comparatively seldom observed in post-mortem examinations. Deposits of lymph are sometimes met with in the kidneys; but these are of small extent, of a light colour, and resemble lymph deposited in consequence of ordinary inflammation. The patches of congestion, so characteristic of this disease in other organs, are not here observed. This may depend upon the peculiar disposition of the capillary system of the kidney. The blood has to pass through the Malpigian tufts, and may be purified, or altered in character, before it reaches the proper venous system of the organ. In cases where purulent infection of the blood has been purposely produced, portions of the kidney will not unfrequently be found inflamed and firmer than natural; but, if the origin of the disease were not known these appearances could not be distinguished from those produced by inflammation of the kidney from other causes.