_Expt._ 6.--Twenty grains were given, dissolved in a little spirit, to a dog of very small size. In a quarter of an hour he was intoxicated; in half an hour he had great difficulty of movement; in an hour he had lost all power over the hinder extremities, which were rather stiff but flexible; sensibility did not seem to be impaired, and the circulation was natural. He readily acknowledged calls by an attempt to rise up. In four hours he was quite well. In none of these or several other experiments was there the least indication of pain, or any degree of convulsive movement observed. It seems needless to dwell on the details of each experiment; suffice it to say that they led to one remarkable result--that while carnivorous animals and fish, dogs, cats, swine, vultures, crows, and adjutants, invariably exhibited the intoxicating influence of the drug, the graminivorous, such as the horse,[4] deer, monkey, goat, sheep, and cow, experienced but trivial effects from any dose we administered. Encouraged by these results, no hesitation could be felt as to the perfect safety of giving the resin of hemp an extensive trial in the cases in which its apparent powers promised the greatest degree of utility. _Cases of Rheumatism treated by Hemp. Catalepsy produced by one grain._ The first cases selected were two of acute rheumatism and one of that disease in the chronic form, occurring among the patients in the Clinical Hospital of the Medical College. In the two former but little relief had been derived from a fair trial of antiphlogistic measures, and of Dover’s powder with antimonials; in the last case, sarsaparilla at first, and subsequently the Hemidesmus Indicus with warm baths had been tried without advantage. On the 6th November, 1838, one grain of the resin of hemp was administered in solution, at two, p.m., to each of these three patients. At four, p.m., it was reported that one was becoming very talkative, was singing songs, calling loudly for an extra supply of food, and declaring himself in perfect health. The other two patients remained unaffected. At six, p.m., I received a report to the same effect, but stating that the first patient was now falling asleep. At eight, p.m., I was alarmed by an emergent note from Nobinchunder Mitter, the clinical clerk on duty, desiring my immediate attendance at the hospital, as the patient’s symptoms were very peculiar and formidable. I went to the hospital without delay, and found him lying on his cot quite insensible, but breathing with perfect regularity, his pulse and skin natural, and the pupils freely contractile on the approach of light. Alarmed and pained beyond description at such a state of things, I hurried to the other patients--found one asleep, the third awake, intelligent, and free from any symptoms of intoxication or alarm.