On account of the impossibility of obtaining the less common organic chemicals in the United States during the past few years, university laboratories have had no option but to prepare their own supplies. At the University of Illinois, for instance, a special study has been made of this field, and methods for the production of various substances have been investigated. As a result, reliable methods and directions have been developed for producing the materials in one-half to five pound lots. Such work as Illinois has done is now being given an even more extensive scope at the Research Laboratory of the Eastman Kodak Company. It is felt that the results from these various laboratories should be available to all chemists and it is hoped that they eventually will be completely incorporated in these pamphlets. The organic chemicals herein discussed have been quite arbitrarily chosen, being those which have been needed in various research laboratories in the last years and for which the directions happen now to be ready for publication. The methods are in only a few cases new ones; they are in general the most satisfactory to be found in the literature. Only such details have been added as will enable a man with a reasonable amount of experience in organic chemistry to duplicate the results without difficulty. To be absolutely sure that each set of directions can be repeated, every experiment has been carried out in at least two laboratories. Only after exact duplication of the results in both laboratories are the directions considered ready for publication. The names of the chemists who have studied the various experiments are given so that further information concerning any obscure point can be obtained if any question arises in using these directions. And finally, in describing the experiments, special attention has been given to the explanation of why it is necessary to follow the directions carefully, and what will happen if these directions are not followed.