Settled at Rouen, he pursued his studies with unremitting devotion, and with only too little regard for his health. His elder sister, who might have won him occasionally to lighter pursuits, was married to her cousin M. Périer in 1641, and two years afterwards went with him to Clermont, where her husband was appointed a Counsellor in the Court of Aides. Jacqueline was absorbed in her own poetical studies, which received a special impetus from the friendship of Corneille, who had returned at this time to his native town. The illustrious dramatist speedily sought out the Pascal family, and became one of their most intimate associates. A prize being given every year for the best copy of verses on the “Conception of the Virgin,” it was awarded to certain verses of Jacqueline’s for the year 1640. When the announcement of the result was made she was absent, but a friend of the family rose and returned thanks in verse in the name of the youthful poetess—_Pour une jeune muse absente_. The friend was Corneille, whose impromptu lines on the occasion, along with those of Jacqueline, are still preserved. {16} Neither have much poetic merit, but they recall an interesting incident. A bright atmosphere of intellectual emulation and cheerful prospects surrounds the family at this time. But all the while it is evident, from Madame Périer’s account, that her brother was injuring his health greatly in his undue assiduity in his scientific pursuits. The attempts to perfect the construction of his arithmetical machine seem especially to have worn out his delicate frame, and to have laid the foundation of the nervous prostration from which he more or less suffered all his life afterwards. “From the age of eighteen,” she says in a significant passage that her brother “hardly ever passed a day without pain. In the intermissions of his sufferings, however, his spirit was such that he was constantly bent on some new discovery.” {17} In the beginning of 1646 an accident happened which had important consequences both to Pascal and his sisters. Étienne Pascal fell upon the ice and severely sprained his foot. During his confinement he was attended by two brothers who had acquired repute in the treatment of such injuries. They were gentlemen of family in the neighbourhood, who had devoted themselves to medicine and anatomy from benevolent instincts and the love of these studies. Both were disciples of a clergyman at Rouville, who was an enthusiastic pietist and friend of St Cyran. Crowds flocked to hear Pastor Guillebert whenever he preached, and many were stirred by his eloquence to devote themselves to pious and philanthropical labours. One of the brothers under this inspiring guidance built a hospital at the end of his park, and gave his children to the service of the Church in various capacities. The other brother, who had no children, provided beds in the hospital and attended the sick poor.