After spending the winter at the East I went to Detroit, Mich., and opened an office in connection with Dr. P. M. Wheaton. I practiced in Detroit for fifteen years, excepting that during the last six years of that time I spent a part of each year at Cleveland, giving a course of lectures on the Theory and Practice of Medicine at the Western Homoeopathic Medical College, of Cleveland, Ohio. When I went to Detroit the prejudice against homoeopathy was very strong, especially among physicians. An attempt was made to pass a bill through the Legislature of Michigan which would virtually prohibit the practice in the State. The bill passed the Senate, but, owing to the prompt action of the friends of homoeopathy in exposing the design of the advocates of the bill, it was defeated in the House of Representatives. The presence of the Asiatic cholera in 1849 in the city, and the success which attended the homoeopathic treatment of that disease, was instrumental in calling the attention of large numbers of the most intelligent and influential citizens to the new practice and establishing it upon a firm basis. When the disease first appeared in the city, we furnished the families which we were accustomed to attend, and all others who desired them, with Veratrum album and Cuprum metallicum, which had been earnestly recommended by Homoeopathic physicians elsewhere, who had had experience in treating the disease, as preventive remedies, a dose or two of each to be taken daily. As a result, very few among the families which we were accustomed to attend were attacked with the disease, and in such cases as occurred the disease was generally readily controlled. As a rule, the most troublesome cases which we had to treat were those in which Opium or morphine in some form had been administered before we were called. In such cases it was exceedingly difficult to get a satisfactory response from our remedies, however carefully we selected them. The Asiatic cholera is a violent disease and rapid in its progress, and if severe cases of this disease are to be treated successfully, it must be by remedies which are prompt in their action. It is here that homoeopathic remedies show their superiority over all other remedies or methods of treatment, for they act upon the diseased organs in the direction of the disease, and thus excite a prompt reaction. Homoeopathic remedies, when properly used, do not benumb, nor do they seriously aggravate existing diseased action; and they neither cause diseased action in well organs, nor reduce the quantity of blood, nor lessen the vitality of the organism and the ability to react against the encroachment of diseased action, as does the allopathic treatment; and, consequently, if a patient dies the physician and his friends have the consolation, at least, of knowing that he did not die from the treatment.