The part played by the kidneys in rapidly eliminating effete material cannot be too carefully safeguarded. Anything which interferes with its work will sooner or later cause a retention of waste-products in the system, and will also permit of the escape of valuable albuminous materials of the substance of the blood through the filtering apparatus. The effect of alcohol upon the kidneys can only be described as disastrous. In proportion as the kidney shrinks, there is a diminution of the excretion of urine, and, finally, the condition known as Bright’s disease is established. _The Effect of Alcohol on the Muscular System._—The muscular tissue forms 43 per cent. of the body weight. It has been proved that under the moderate use of alcohol the muscles become flabby and less vigorous and effective; that troops cannot work or march on alcohol; that in training for athletics, for races, or for other sports, total abstinence is always practised; the true sportsman depends quite as much on his brain as on his muscles for success. In England it is recognized that total abstinence is a necessity where great exertions are concerned, and it is now beyond all question that alcohol, in even so-called dietetic quantities, diminishes the output of muscular work, both in quantity and quality, and that the best physical results are obtained under total abstinence from its use. Alcohol actually lowers the temperature of the body from three-fourths of one degree to three degrees. This depression of temperature is not transient, but lasts for several days, so that its use, when the person is exposed to intense cold, is extremely hazardous to life. _The Effects of Alcohol on the Nervous System._—Kraepelin has carried out a series of experiments to prove the effects of small doses of alcohol on the output of work. In all mental work there are two elements to be considered, namely, quality and speed. Now, all observers are agreed that the quality of mental work is affected even before speed, more mistakes being made. Tests were made in reading aloud; in adding figures in various combinations; in type-setting; and in memorizing; in all these instances it was found that, after taking moderate doses of alcohol for a number of consecutive days, the work done was less, was less accurate, and that there was a decrease in the power of memorizing. Another series of investigations, made by Rudin to determine how long the intellectual abilities continue to be depressed after the effects of alcohol pass off, showed that the effects of a single dose of alcohol persisted until noon or evening of the next day.