In 1859 the descent of John Brown upon Harper's Ferry, and his capture, trial, and death, startled the nation. When the news reached her that the misguided but noble old man lay desperately wounded in prison, alone and unfriended, she wrote him a letter, under cover of one to Governor Wise, asking permission to go and nurse and care for him. The expected arrival of Captain Brown's wife made her generous offer unnecessary. The prisoner wrote her, thanking her, and asking her to help his family, a request with which she faithfully complied. With his letter came one from Governor Wise, in courteous reproval of her sympathy for John Brown. To this she responded in an able and effective manner. Her reply found its way from Virginia to the New York Tribune, and soon after Mrs. Mason, of King George's County, wife of Senator Mason, the author of the infamous Fugitive Slave Law, wrote her a vehement letter, commencing with threats of future damnation, and ending with assuring her that "no Southerner, after reading her letter to Governor Wise, ought to read a line of her composition, or touch a magazine which bore her name in its list of contributors." To this she wrote a calm, dignified reply, declining to dwell on the fierce invectives of her assailant, and wishing her well here and hereafter. She would not debate the specific merits or demerits of a man whose body was in charge of the courts, and whose reputation was sure to be in charge of posterity. "Men," she continues, "are of small consequence in comparison with principles, and the principle for which John Brown died is the question at issue between us." These letters were soon published in pamphlet form, and had the immense circulation of 300,000 copies. In 1867 she published _A Romance of the Republic_, a story of the days of slavery; powerful in its delineation of some of the saddest as well as the most dramatic conditions of master and slave in the Southern States. Her husband, who had been long an invalid, died in 1874. After his death her home, in winter especially, became a lonely one, and in 1877 she began to spend the cold months in Boston.