It may be noted that it comes out in a profession of faith drawn especially to exclude the association of the Son of Mary with God. Thus Mohammed crowns the work which Arius attempted three hundred years before. After the restless heresies in which the Greek mind had fluctuated during these three centuries, the greatest enemy to the Greek empire and faith was set up on that very negation of the godhead of Christ with which those heresies had begun. Fifty years of Arian success, in which the emperors, Constantius and Valens, take a large part, inspired and supported by Eusebius, Macedonius, Eudoxius, and Demophilus, four successive bishops of Byzantium, cause that disorganisation of the eastern Church which St. Basil described as its ruin. Fifty years of patronising the Monothelite heresy, in which the emperors Heraclius and Constans II. bear the largest part, supported by four Byzantine patriarchs, Sergius, Pyrrhus, Paulus, and Peter, beginning in 628, mark the rise and accompany the establishment of the Mohammedan empire and creed. Honorius dies before the heresy is presented for acceptance in Rome in the imperial Ecthesis. Ten Popes succeeding Honorius, in spite of the temporal distress which surrounds them, oppose to the utmost the Byzantine heresy and despotism in the midst of whom one gloriously lays down his life and is martyred by the eastern emperor as guilty of high treason. This is the connection between Arius and Mohammed, who appears as the divine punishment and remedy for Byzantine successors of Constantine who would confiscate the liberty of the church, and for state-made patriarchs who foster and formulate heresy.