Pharmacologia: Fourth American, from the Seventh London EditionParis, John Ayrton
Science
Pharmacologia: Fourth American, from the Seventh London Edition
Paris, John Ayrton
Pharmacognosy; Pharmacology; Pharmacy
_Water_ will on some occasions be found a convenient expedient; powdered
_Rhubarb_ or _Jalap_ may be thus made into masses without any increase
of bulk, but the pills will be apt, if kept, to become mouldy.
3. In the formation of pills the ingredients should be hastily rubbed
together, whenever they are liable to be injured by long exposure to the
air; thus in the formation of _Pilulæ Hydrargyri submuriatis compositæ_,
the compound is rendered less active by too long continued triture. See
_Pulveres_.
4. In dividing pill-masses, it is usual to add to them, and envelope
them in, magnesia; where calomel is present, I have satisfied myself by
experiment that a _muriate of magnesia_ is formed under such
circumstances, and it is owing to this partial decomposition, that the
surface of the pill exhibits a greenish hue; starch, powder of
liquorice,[299] or orrice root, might perhaps under such circumstances
be more judiciously preferred. In Germany, the powder of _Lycopodium_ is
generally used. Formerly, the pill was covered with gold leaf, which
protected it from the influence of the stomach, and frequently rendered
it unavailing.
It has been observed that many of the pill-masses directed in our
Pharmacopœias, are liable to become so hard[300] and dry by being kept,
that they are unfit for that division for which they were originally
intended; indeed Dr. Powel considers it doubtful whether the greater
number of articles had not better be kept in powder, and their
application to the formation of pills left to extemporaneous direction;
the necessity of this is farther apparent, when we learn that it is a
common practice for the dispenser to soften these masses by the
application of a hot spatula, or pestle, which sometimes carbonizes, and
frequently decomposes them.
III. THEIR FORM OF PRESCRIPTION.
In our extemporaneous directions, it is necessary to apportion with
accuracy the quantity of active materials which we may wish each pill to
contain, and since the proportion of the _constituent_ can rarely be
exactly defined, the equable division of the whole mass, into a given
number of pills, will be safer than defining the weight of each pill.
A pill, the bulk of whose ingredient is vegetable matter, ought not to
exceed five grains in weight, but where the substances which compose it
are metallic and ponderous, it may without inconvenience weigh six or
even eight grains.
TROCHISCI. _Troches_, or _Lozenges_.
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