Pharmacologia: Fourth American, from the Seventh London EditionParis, John Ayrton
Science
Pharmacologia: Fourth American, from the Seventh London Edition
Paris, John Ayrton
Pharmacognosy; Pharmacology; Pharmacy
Rhubarb is equally incompatible: the extract of this substance therefore
never ought to be employed in forming pills of tartar emetic: but it
deserves notice that this salt is not decomposed by the infusions of
gentian or wormwood. The _Alkaline Sulphates_, provided they be
perfectly neutral, produce no disturbance in solutions of _tartar
emetic_, and therefore cannot be considered incompatible with them; if
there be any excess of acid, as in _alum_, _bi-sulphate of potass_, &c.
then its decomposition is effected, and a white insoluble sulphate of
antimony is precipitated. It appears therefore that the famous
“Emeto-purgative” of the French school, consisting of sulphate of soda,
and tartarized antimony in solution, is by no means the unchemical
mixture which some have considered it to be, and that it really produces
its effects from the operation of its original ingredients, and not from
that of the compounds (_Sulphate of Antimony, Tartrate of Soda, and
Sulphate of Potass_) which have been erroneously supposed to result.
FORMS OF EXHIBITION. Solution is its best form, see _Liquor Antimonii
Tartarizati_. DOSE. It either vomits, purges, or sweats, according to
the quantity exhibited; thus gr. 1/4 will, if the skin be kept warm,
promote a diaphoresis; gr. ½ will procure some stools first, and
sweating afterwards; and gr. j will generally vomit and then purge, and
lastly sweat the patient; in very minute doses, as gr. 1/10 or 1/12
combined with squill and ammoniacum, it acts as an expectorant, see
_Formulæ 1, 2, 3, 8, 60_. It is decidedly the most manageable, and the
least uncertain of all the antimonial preparations, and the practitioner
would probably have but little to regret, were all the other
combinations of this metal discarded from our pharmacopœias. Some
authors have considered this substance as possessing sedative powers,
independent of its nauseating and diaphoretic effects. It undoubtedly
acts upon the heart, and controls the force of the circulation in
fevers, without occasioning any other sensible effect. Mr. Brodie, after
having given large doses of this salt to animals, found that the heart
beat very feebly, and although artificial respiration was kept up, it
soon ceased to act altogether. Lenthois of Montpellier advises small
doses of it in incipient phthisis, and it would on some occasions appear
to diminish the febrile excitement. The following is the form in which
Dr. Lenthois recommends it to be exhibited upon such occasions. He
directs a grain of Tartarized Antimony to be dissolved in eight table
spoonsful of distilled water, which are to be added to six or eight
pints of water, and to be taken as common drink. Tartar emetic, when
triturated with lard, in the proportion of ʒiss or ʒij to ℥j of the
latter, forms a very powerful rubefacient, occasioning a pustular
eruption on the skin, and proving very serviceable in deep-seated
inflammation; or the application may be made by dusting a piece of
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