If these stones came into the bladder in 1734, they must, in so many years as his Lordship lived after this, have acquired a very great bulk: nay, if we suppose them not to have been lodged in the bladder above a year before they began to occasion frequent inclination to make urine, with pain, and sometimes sudden stoppages of urine; yet, from 1746 to 1757, they ought to have grown to a much larger size than that of the kernel of a Spanish nut[127]. ’Tis true, the stone may increase faster in some patients, and slower in others; but stones, after remaining a dozen or more years in the bladder, generally weigh several ounces. Some years since l saw a stone, weighing near six ounces, taken from a boy of no more than 14 years of age. 3. Lord Walpole’s case not only shews the power of soap and lime-water to relieve the painful symptoms, and prevent the increase, of the stone in the bladder, but also makes it probable, that these medicines do communicate to the urine a power of dissolving the stone. In the beginning of 1749 his Lordship voided with his urine a calculous substance of a flat shape, about the bigness of a silver penny, and covered with a soft white _mucus_[128]; and upon the surfaces of the stones found in his bladder there were some inequalities, which seemed to have been made by the separation of thin _lamellæ_ or scales. Further, the small stone found in the beginning of the _urethra_ must have been in a dissolving state, and considerably lessened in the bulk: for, if it had lain long in the bladder, and never been larger, it ought to have been voided thro’ the _urethra_ with the urine; and it could not have arrived lately in the bladder, since Lord Walpole had not had, for several years before his death, any nephritic pains, or symptoms of stones passing from the kidnies; and since it is not likely, that a stone of the size and shape of the seed of an apple[129] would pass thro’ the ureters without being felt. Now if this small stone, found in the _urethra_, was partly dissolved by the virtue of the soap and lime-water; it will appear at least probable, that the two larger stones in the bladder were so likewise. But altho’ Lord Watpole’s calculous concretions had remained undiminished, and without any symptoms of dissolution; it would not therefore follow, that soap and lime-water cannot dissolve the stone in other patients, where the concretion may be of a less firm texture.