The Revᵈ. Dr. Richard Newcome, now Lord Bishop of Llandaff, while drinking two English quarts of lime-water daily, for the cure of the stone in his bladder, poured his urine every morning and evening upon a piece of human _calculus_ weighing 31 grains; by which, in the space of four months, it was reduced to three pieces, weighing in all only six grains. Upon one of these pieces, weighing 2.31 grains, he caused to be daily poured, for two months, the fresh urine of a person, who drank no lime-water; at the end of which time the piece of _calculus_ was found to weigh 2.56 grains, having increased in weight a quarter of a grain. This same piece being afterwards steeped in the bishop’s urine (who continued to drink lime-water as above), from June 24th to July 9th, was in these few days quite crumbled into powder. Since this experiment shews, beyond dispute, that lime-water, unassisted by soap, can communicate to the urine a power of dissolving the stone out of the body, it can scarcely be doubted, that it must have the like effect on it, when lodged in the bladder. And that the dissolution of the stone in the bladder has been completed by soap alone, appeared evidently in the case of the Rev. Mr. Matthew Simson, Minister of Pancaitland near Edinburgh; an account of which will soon be made public[130] by Dr. Austin, who opened his body after death. Mr. Simson had, from 1730, been afflicted in a less or greater degree with the symptoms of a stone in the bladder; and in November 1735 was sounded by Dr. Drummond of Perth, and Mr. Balderston, surgeon in this city, by whom a stone was not only plainly felt, but also by the patient himself. In February 1737 he began to take soap; and after 1743 never had any gravelish symptoms. He died in May 1756; and, when his bladder was looked into, there was neither stone nor gravel found in it. 4. It appears from Lord Walpole’s case, that soap and lime-water, even when taken in large quantities, proceed very slowly in dissolving the stone.