It is now about 25 or 30 years since a very particular disease shewed itself in many persons in this island Grande Terre. Its beginning is imperceptible: there appear but a few livid-red spots upon the skins of the white people, and of a yellowish red upon the blacks. These spots in the beginning are not accompanied with pain, or any other symptom; but nothing can take them away. The disease increases insensibly, and continues several years in shewing itself more and more. These spots increase, and extend indifferently over the skin of the whole body. Sometimes they are a little prominent, but flat. When the disease makes a progress, the upper part of the nose swells, the nostrils are enlarged, the nose becomes softened; tuberosities appear upon the cheek-bones; the eyebrows are inflated; the ears grow thick; the ends of the fingers, and even the feet and toes, swell; the nails become scaly; the joints of the feet and hands separate and mortify: ulcers of a deep and of a dry nature are found in the palms of the hands and soles of the feet, which grow well, and return again. In short, when the disease is in its last stage, the patient becomes frightful, and falls to pieces. All these symptoms come on by very slow degrees, one after another, and sometimes require many years to shew themselves: the patient is sensible of no sharp pain; but feels a kind of numbness in his hands and feet. These people perform their natural functions all the while, eating and drinking as usual: and even when the mortification has taken off the fingers and toes, the only ill consequence, that attends, is the loss of those parts, that drop off by the mortification; for the wound heals of itself, without any application: but when it comes to its last period, the poor sick persons are horribly deformed, and truly worthy of compassion. This shocking disease is observed to have several other unhappy characters; as, 1st, that it is hereditary, and that some families are more apt to be seized with it than others: 2dly, that it is infectious, being communicated _per coitum_, and also caught by keeping company with those so diseased: 3dly, that it is incurable, or at least that no remedy has yet been found to cure it. They have in vain tried mercurials, sudorifics, and every other regimen used in venereal complaints, under a notion, that this leprosy was the consequence of some venereal taint: but, instead of being of service, these methods rather served to destroy the patients; for, far from lessening the disease, the antivenereal medicines unlocked the distemper, the most dreadful symptoms appeared, and all those so treated perished some years sooner than the others, who did not take these medicines.