appearance, brilliant and silvery. Moreover all the organs of this side were red, inflamed and swelled by the presence of the foreign body, and it was curious to see the half of the thyroid gland, the tongue, the cheeks and the lips thus red and inflamed to the median line, whilst the other half was sound and pale; the left brain was slightly inflamed and especially the plexus choroides. Besides, I was unable to discover a globule of quicksilver in any of the other organs.” “_Third Experiment._ I forced with a pewter syringe into the crural artery of a large dog, a drachm and a half of quicksilver mixed with common water. The animal, immediately after the double ligature, did not manifest any sign of pain, and walked, bearing less on that limb, which was very sensibly cold, though not paralyzed. But about an hour after, he refused food, manifested by piercing cries acute pain, constant agitation, frequent change of place, and a very evident state of suffering; the limb soon after grew warm, became hot to the touch, with an obscure pulse under the tendo Achillis. This state of fever and pain continued the whole day and night. The next day, the limb was swollen and exhibited a phlegmonous œdema preserving the impression of the finger; the plaintive cries were continual. On the third day his condition was still worse, and I then killed him from compassion sixty hours after the injection. I had carefully noticed the matter of the excretions, without discovering a particle of quicksilver in them. On examination of the body, I could not discover it in any organ, except the limb subjected to the experiment, which was swollen, inflamed and oedematous in all its textures; we observed abscesses in it of different sizes, containing quicksilver, pus, sanies and much gas, coming from the incipient gangrene of the parts; the metal usually occupied the centre of all the abscesses; the mercurial globules flowed out when I cut the skin, the cellular texture, the muscles and especially the small arteries, which were admirably injected by it; gelatinous exudations occupied the interstices of the muscles.”