Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crossesCastle, William E. (William Ernest)
Science
Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crosses
Castle, William E. (William Ernest)
Heredity
A sixth and final generation in this return-selection experiment is
summarized in Table 36. It includes 36 offspring of mean grade -0.39, the
mean of the parents being -0.26, a regression of 0.13 away from 0. It
will be seen, therefore, that the effect of the six original selections
had not been entirely overcome by an equal number of return selections.
The reason for this is obvious. Much smaller numbers are concerned in
the return selections than in the original minus selections. The return
selections are accordingly less efficient. Nevertheless, after the sixth
return selection we find that 1 in 6 of the offspring have plus grades
and their average is lower (that is, _less minus_) than the offspring in
the minus series after a single generation of selection. (Cf. Tables 16
and 36.)
The amount and persistency of the reversed regression in this series
show clearly that return selection is not easier or more rapid than the
original modification of the race by selection, but that selection in
either a plus or minus direction has cumulative and permanent effects.
Further support for this conclusion is furnished by return selections
(one each) made from the seventh generation, from the eighth generation,
and from the eleventh generation of the minus selection series. (See
Tables 37, 38, and 39.) Generation 7 (Table 22) was produced by parents
of average grade -2.01. Their offspring were of average grade -1.73, a
regression (toward 0) amounting to 0.28. Certain pairs of these offspring
of grade -0.75 and -0.87 (mean -0.78) constitute the return selection
from generation 7 (Table 37). They had 33 offspring of average grade
-1.15, a regression _away from_ 0 amounting to 0.37.
Generation 8 of the minus-selection series (Table 23) was produced by
parents of mean grade -2.05. Their offspring were of mean grade -1.80, a
regression (toward 0) of 0.25. Certain pairs of these offspring of grades
-0.50, -0.62, and -1.00 (mean -0.72), when chosen as parents, produced 41
young of mean grade -1.51, a regression _away from_ 0 amounting to 0.79.
(See Table 38.)
Generation 11 of the minus series (Table 26) was produced by parents of
mean grade -2.30. The offspring were of mean grade -2.15, a regression
of 0.15 toward 0. A pair of the offspring of mean grade -1.62 (Table
39) produced 16 young of mean grade -1.95, a regression of 0.32 away
from 0. This result shows that the selected race had now passed the
point represented by the grade of the parents (-1.62) and the offspring
regressed toward a racial mean as advanced as the most extreme
individuals obtained previous to selection.
To show that, in the plus selection series, a return selection has a
result similar to that just described, two experiments may be cited:
Public-domain text, read in full here on John Shaqi.
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