Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crossesCastle, William E. (William Ernest)
Science
Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crosses
Castle, William E. (William Ernest)
Heredity
A third cross in which the minus series is concerned was made between
females of grade -2 and -2.25, generation 10, and wild males. The F₂
offspring include 91 hooded individuals classified as to grade in the
third row of Table 42. Their mean grade is +0.24, confirming fully the
results obtained in the two previous experiments.
With these three cases we may compare three cases in which animals of the
plus selection series were crossed with a wild male. (See the last three
rows of Table 42.) Females of grade +3.00, generation 3, were crossed
with a wild male. From this mating resulted 21 hooded grandchildren,
ranging in grade from +1.75 to +3.50, mean +2.56. These grandchildren,
it will be observed, in no case are of minus grade, as are about half
the grandchildren when the grandparent is of minus grade. There is also
no clear evidence of modification of the hooded character by the cross
in this case. The grade of the extracted hooded individual is just about
what uncrossed individuals of grade +3.00 produced in the corresponding
generation of the plus series.
In the next case two females of the plus series, belonging to generations
5 and 6, respectively, were crossed with a wild male and their children
were bred _inter se_. There resulted 38 hooded grandchildren, as shown in
the next to the last row of Table 42. The range of the grades of these
hooded grandchildren was similar to that of the grandchildren in the
foregoing case, but their mean was somewhat higher, as we should expect,
since they are descended from more highly selected individuals; for the
hooded grandparents in this case were of grade +3.25 (generation 5) and
+3.50 (generation 6), whereas the grandparent in the foregoing case was
of grade +3.00 (generation 3).
It is a noteworthy fact that in both these cases the wild cross does not
seem to have increased the pigmentation in extracted hooded individuals,
as it did when the minus series was crossed, but rather to have
diminished it; yet the difference between observed and expected is not
great. We might disregard it altogether, if a similar but more striking
result were not observable in the third case as well as in another series
of crosses presently to be described.
The third case (last row of Table 42) involves a cross between a female
of grade +4.25, generation 10, plus series, and a wild male. The F₂
offspring include 16 hooded individuals of mean grade +3.15. Animals of
this grade in the uncrossed race in this generation produced young of
mean grade +3.84.
Before leaving this subject it is important to observe the considerable
difference between the extracted hooded grandchildren of the
minus-series rats, as a group, and those of the plus series. The latter
is unmistakably a plus-series group; the former is on the border line
between the two series. (Cf. Plates 2 and 3.)
CROSSES WITH BLACK “IRISH” RATS.
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