Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crossesCastle, William E. (William Ernest)
Science
Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crosses
Castle, William E. (William Ernest)
Heredity
The upper group in F₂ should contain a larger proportion of homozygous
mutants than in F₁, and since the parents of F₃ were chosen from
this upper group of F₂ offspring, it is not surprising that the 11
F₃ offspring recorded up to this time all fall in the upper group.
The mean of this upper group is remarkably constant through the three
generations, and the variability of the group as measured by its
standard deviation is also low, namely, 0.19. This indicates that the
mutant character is a strongly dominant unit in relation to the ordinary
condition of the plus series.
Table 54 shows the character of the F₂ offspring of the original male
mutant mated with females of the plus series. The lower group parents,
those into which the mutant character did not presumably enter at all,
produced 59 offspring recorded in the first part of Table 54. Their mean
grade is 3.78 and their standard deviation 0.33. These are very close to
the constants of the general plus series, which for generation 10 were
3.73 and 0.36, respectively.
The second division of Table 54 shows the character of the young produced
by the F₁ parents of the upper group (Table 51). Such parents are
supposed to have received a “mutant” gamete from their father, grade
about 5.50, and a plus-series gamete from their mother, grade about 3.75.
If they produce gametes of these same two sorts, their offspring should
also fall into two corresponding groups; in fact they do. There are 11
offspring of mean grade 3.86 and 79 offspring of mean grade 5.50. As in
the previous generation, the two groups do not approach each other in
grade. The mean and standard deviation of the lower group of offspring
are similar to those of the plus race. The mean of the upper group is
about the same as that of their parents (upper group of offspring, Table
51), namely, 5.50, as compared with 5.45; their standard deviation
is somewhat lower, namely, 0.15, as compared with 0.23. This result
indicates that the “mutant” character and the hooded character of the
plus series segregate from each other in a simple way without modifying
each other appreciably. It seems possible that they contain the _same
modifiers_ (if modifiers are present) and differ merely by the main unit
which we called the hooded character in the early part of this paper.
Each contains a different condition of that main unit. Consequently
there is no increase of variability in F₂ when these two conditions are
intercrossed. This we should expect to happen, if they differed by more
than a single factor.
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