In the meantime the great impetus given to the study of radioactivity abroad led to a rapid succession of new discoveries. Many scientists engaged in the search for other radio elements, using the new method of chemical analysis, with the aid of radiation, that we had inaugurated. Thus were found the mesothorium now used by physicians and manufactured industrially, radio-thorium, ionium, protoactinium, radio-lead, and other substances. At present we know, in all, about thirty radio elements (among which three are gases, or emanations), but among them all radium still plays the most important part, because of the great intensity of its radiation, which diminishes only extremely slowly during the course of years. The year 1903 was especially important in the development of the new science. In this year the investigation of radium, the new chemical element, was achieved, and Pierre Curie demonstrated the astonishing discharge of heat by this element, which nevertheless remained unaltered in appearance. In England, Ramsay and Soddy announced a great discovery. They proved that radium continually produces helium gas and under conditions that force one to believe in an atomic transformation. If, indeed, radium salt heated to its melting point is confined for some time in a sealed glass tube, entirely emptied of air, one can, in reheating it, make it throw off a small quantity of helium, easy to measure and to recognize from the character of its spectrum. This fundamental experiment has received numerous confirmations. It furnished us the first example of a transformation of atoms, independent, it is true, of our will, but at the same time it reduces to nothing the theory of the absolute fixity of the atomic edifice. All these facts, along with others formerly known, were made the object of a synthesis of the highest value, in a work by E. Rutherford and F. Soddy, who proposed a theory of radioactive transformations, to-day universally adopted. According to this theory, each radio element, even when it appears unchanged, is undergoing a spontaneous transformation, and the more rapid the transformation, the more intense is the radiation.[12]