----------------+--------+------+-------+-------------------------------- NOTE.--The bubo in Nos. 2, 5, and 24 never opened spontaneously. The pus was aspirated at the time of the second, eventually third, examination. Nos. 11 and 19 opened spontaneously. A fistula formed along the canal which was caused by the puncture, and healed up in several weeks. Hard inguinal buboes of secondary order persisted in patient 19 at the time of second examination. No plague bacilli were found either in the bubo of the first or second order. Patient 20 had a considerable amount of pus in the inguinal primary bubo, but it was not opened until after the last examination. Two of the patients, cases 8 and 12, had numerous plague bacilli in the sputum at the time when the expectoration showed the presence of blood (twenty-three and one-half and eighty-two hours, respectively, before death). In 3 cases I was able to prove the presence of _Bacillus pestis_ in the skin lesions, _intra vitam_, fifteen, twenty-two, and forty-eight hours, respectively, before death. In case 18 there was no doubt that the skin lesions, which covered the whole body and the face, were of secondary nature, as the patient died shortly afterward. It was undoubtedly a case similar to those reported by Gotschlich and Zabolotny.[5] In the other two patients there was only 1 maculopapulous efflorescence on the foot in case 1 (with a corresponding femoral bubo) and 2 lesions of the same type on the arm and forearm in case 4 (with a corresponding axillary bubo). It is possible that these lesions were the original port of entry of infection. Numerous plague bacilli were found in the skin lesions of these cases, both microscopically and in culture. [5] Kolle und Wassermann: Handbuch der pathogenen Mikroorganismen. Gustav Fischer, Jena (1903), =2=, 521. The plague patients tabulated in Table II recovered. They were all treated with antiplague serum. While cases 5, 11, 19, and 24 appeared clinically to be rather severe, cases 2 and 20 were mild. It can be seen from the table that the plague bacilli may not be detected in the enlarged gland at first (case 2) and that their presence may be revealed only after repeated examination of the bubo. It is also evident from the results of repeated examinations that the plague bacilli disappear from the infected gland in a comparatively short time, as a rule at the time when pus starts to form. Contrary to the findings in patients who died, distinct phagocytosis was noticed in the smears made from the aspirated liquid in those patients who recovered and who had been treated with serum soon after the onset of the disease. It is undoubtedly this process that clears the gland of the infectious agents.