The general opinion in regard to the presence of _Bacillus pestis_ in the circulating blood seems to have been, as Thompson remarks, that "the bacillus is rarely to be found in the peripheral blood stream before the agonal stage."[6] [6] Journ. Hyg., Cambridge (1906), =6=, 558. The Austrian Commission, using few drops of blood, found positive blood culture in 40 per cent; Calvert in Manila in 100 per cent when examined twenty-four hours before death; Choksy, Berestneff, and Mayr in 45 per cent; and Greig in 60 per cent. The Indian Commission examined 28 patients, and obtained positive blood cultures in 16 out of 23 fatal cases. Not a single positive blood culture was obtained from the patients who survived. The time of blood examination in positive cases was three and one-half to seventy-five and one-half hours before death. The amount of blood used was 1 cubic centimetre. Only 6 out of the 30 samples, which gave positive blood culture, were found positive by microscopical examination of blood smears. The following conclusions are based on these observations in regard to the septicæmic stage of bubonic plague: (1) "A severe septicæmia may be present at a comparatively early stage of the disease and for a considerable number of hours before death, and (2) the septicæmia may be of an irregular and fluctuating type."[7] [7] _Ibid._ (1907), =7=, 395. From the tables it will be seen that out of 15 patients examined by me, 14 gave positive blood culture; and of these 3 recovered. One blood culture revealed the presence of streptococcus in addition to _Bacillus pestis_. The results of the examinations tabulated in Tables I and II show, in agreement with the findings of the Indian Commission, the occasional early occurrence of plague bacilli in the blood stream, as the time of examination in the positive cases varied from one hour to one hundred six hours before death. In consideration of the ephemeral character of the septicæmic stage of plague, as evidenced by repeated blood cultures in the three patients who recovered, one can hardly avoid the impression that there is a certain degree of septicæmia in every case of plague. The possibility of detecting the bacillus in the circulating blood increases in proportion with the quantity of blood used for culture. The best chance to recover plague bacilli from the circulating blood seems to be in the stage of high fever and general prostration.