Because of the spider’s nocturnal and retiring habits few people are bitten, in spite of a large spider population. According to an article in the August, 1963 Journal of the Arkansas Medical Society, “there may be mild transitory stinging at the time of the bite, but there is little associated early pain. The patient may be completely unaware he has been bitten, and the spider is seldom seen. Only after 2 to 8 hours does pain, varying from mild to severe, begin. After several days an ulcer may form at the site of the bite. The venom appears to contain a spreading factor resulting in a spread of the necrosis or tissue destruction. In some instances, the ulcer may be so large that skin grafting is required, but the graft may take poorly or not at all. “The bite may also produce serious systemic symptoms including fever, chills, weakness, vomiting, joint pain, and a spotty skin eruption, all occurring within 24-48 hours after the venom injection.” Treatment for bite of the brown recluse spider Physicians at the University of Arkansas Medical Center, Little Rock, prefer the prompt administration of corticosteroids, stating, “Large doses given early may completely prevent the gangrenous response as well as the systemic reaction. The dosage schedule which we have found most effective is: 80 mg. of methylprednisolone (Deep-Medrol) intramuscularly immediately followed by one or two additional doses of same amount at 24-48 hour intervals. Subsequently, step wise decrease to 40, 20, 10 mg., every 24-48 hours, depending on the patient’s response, is carried out.” Dr. Herbert L Stahnke, Director of the Arizona Poisonous Animals Research Laboratory, reports that an antivenin has been prepared in South America to control both the local and general symptoms from the bite of a closely related species of _Loxosceles_. He states, “locally there seems to be a favorable response to hydroxyzine, 100 mg. four times a day. I would say that cryotherapy, as we recommend it, would prevent all symptoms. I would recommend that the site of the bite be packed in crushed ice for 6 to 8 hours, after which the patient should be kept warm to the point of perspiration with the ice pack continuing for a total of 24 hours. In other words, treated like a pit viper bite, but over a much shorter period of time.” Avoid narcotics (morphine, demerol, dilaudid, codeine, etc.) since they enhance the systemic effects.