328. General Composition of Tobacco, 269, 270 329. Quantitative Estimation of Nicotine in Tobacco, 270, 271 330. Nicotine; its Properties and Tests, 271-273 331. Effects of Nicotine on Animals, 273, 274 332. Effects of Nicotine on Man, 274, 275 333. Some Instances of Poisoning by Tobacco and Tobacco Juice, 275-277 334. Physiological Action of Nicotine, 277, 278 335. Fatal Dose, 278 336. _Post-mortem_ Appearances, 278 337. Separation of Nicotine from Organic Matters, &c., 278, 279 3. _Piturie._ 338. Properties of Piturie, 279 4. _Sparteine._ 339. Properties of Sparteine, 279, 280 5. _Aniline._ 340. Properties of Aniline, 280 341. Symptoms and Effects, 280, 281 342. Fatal Dose, 281 343. Detection of Aniline, 281 III. THE OPIUM GROUP OF ALKALOIDS. 344. General Composition of Opium, 281, 282 345. Action of Solvents on Opium, 282, 283 346. The Methods of Teschemacher and Smith, of Dott and others for the Assay of Opium, 283, 284 347. Medicinal and other Preparations of Opium, 284-288 348. Statistics of Opiate Poisoning, 288, 289 349. Poisoning of Children by Opium, 289 350. Doses of Opium and Morphine--Fatal Dose, 289, 290 351. General Method for the Detection of Opium, 290, 291 352. Morphine; its Properties, 291, 292 353. Morphine Salts; their Solubility, 292, 293 354. Constitution of Morphine, 293, 294 355. Tests for Morphine and its Compounds--Production of Morphine Hydriodide--Iodic Acid Test and other Reactions--Transformation of Morphine into Codeine, 294-296 356. Symptoms of Opium and Morphine Poisoning--Action on Animals, 296-298 357. Physiological Action, 298, 299 358. Physiological Action of Morphine Derivatives, 299 359. Action on Man--(_a_) The Sudden Form; (_b_) the Convulsive Form; (_c_) a Remittent Form of Opium Poisoning--Illustrative Cases, 299-303 360. Diagnosis of Opium Poisoning, 303, 304 361.