Poisons, Their Effects and Detection: A Manual for the Use of Analytical Chemists and ExpertsBlyth, Alexander Wynter
Science
Poisons, Their Effects and Detection: A Manual for the Use of Analytical Chemists and Experts
Blyth, Alexander Wynter
Poisons
§ 120. =Action on Warm-Blooded Animals.=--If a sufficient quantity
of a solution of a potassic salt is injected into the blood-vessels
of an animal, there is almost immediate death from arrest of the
heart’s action. Smaller doses, subcutaneously applied, produce
slowing of the pulse, dyspnœa, and convulsions, ending in death.
Small doses produce a transitory diminution of the force of arterial
pressure, which quickly passes, and the blood-pressure rises. There
is at first, for a few seconds, increase in the number of
pulsations, but later a remarkable slowing of the pulse. The rise in
the blood-pressure occurs even after section of the spinal cord.
Somewhat larger doses cause rapid lowering of the blood-pressure,
and apparent cessation of the heart’s action; but if the thorax be
then opened, the heart is seen to be contracting regularly, making
some 120-160 rhythmic movements in the minute. If the respiration be
now artificially maintained, and suitable pressure made on the walls
of the chest, so as to empty the heart of blood, the blood-pressure
quickly rises, and natural respiration may follow. An animal which
lay thirty-six minutes apparently dead was in this way brought to
life again (_Böhm_). The action of the salts of potassium on the
blood is the same as that of sodium salts. The blood is coloured a
brighter red, and the form of the corpuscles changed; they become
shrivelled through loss of water. Voluntary muscle loses quickly its
contractility when a solution of potash is injected into its
vessels. Nerves also, when treated with a 1 per cent. solution of
potassic chloride, become inexcitable.
§ 121. =Elimination.=--The potassium salts appear to leave the body
through the kidneys, but are excreted much more slowly than the
corresponding sodium salts. Thus, after injection of 4 grms. of
potassic chloride--in the first sixteen hours ·748 grm. of KCl was
excreted in the urine, and in the following twenty-four hours 2·677
grms.
§ 122. =Nitrate of Potash= (KNO₃).--Pure potassic nitrate
crystallises in large anhydrous hexagonal prisms with dihedral
summits; it does not absorb water, and does not deliquesce. Its
fusing point is about 340°; when melted it forms a transparent
liquid, and loses a little of its oxygen, but this is for the most
part retained by the liquid given off when the salt solidifies. At a
red-heat it evolves oxygen, and is reduced first to nitrite; if the
heat is continued, potassic oxide remains. The specific gravity of
the fused salt is 2·06. It is not very soluble in cold water, 100
parts dissolving only 26 at 15·6°; but boiling water dissolves it
freely, 100 parts dissolving 240 of the salt.
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